Education and Career Background
Mikhail Blagosklonny is an oncology professor, employed at the prestigious Roswell Cancer Institute. One of the most famous of his works is the theory that seeks to relate aging with cancer. He graduated with a medical degree from the First Pavlov State Medical University of St. Petersburg, Russia. Later, he attained a doctorate in cardiology and experimental medicine from the same institution.
He started practicing as an associate professor at the New York Medical College. Ordway research was the next stop for him, a position he held until 2009. He later joined Roswell where he has rose through the ranks and become a leading oncology researcher.
The Role of TOR in the Aging Process
Contrary to popular belief, aging is not caused by damages resulting from pathogens, stress or physical injuries and impacts. Mikhail Blagosklonny has come with a theory that seeks to abolish the belief that aging is as a consequence of the agglomeration of cellular damages. Visit ResearchGate to keep up to date with Mikhail’s latest work.
Through research, Mikhail has established that TOR (Target of Rapamycin) signaling plays a significant part in the acceleration of aging. Though the accumulation of cellular damage might be partially correct, Mikhail argues that most organisms die before the injuries deplete the cells. He says that his research has proven that TOR is an aging catalyst. In a normal human being, Tor stimulates cell growth, which is kept in check by cell division, however, when the cell division fails due to other factors and TOR is still active, cells start to malfunction. As a result conditions such as high blood pressure, cancers, Alzheimer’s, and other old age diseases start affecting the patient.
A remedy to this catastrophe is slowing down aging or increasing age tolerance. Since TOR causes aging, inhibiting its pathway and taking Rapamycin which has proven to extend lives of yeast and mice, can significantly elongate life. Rapamycin works by ensuring the cellular cycle does not fail, resulting in cellular senescence. Physical exercise also considerably contributes towards aging inhibition.
Age tolerance can be increased by inducing damaging stresses. This protects humans from the harmful consequences of aging-related diseases by familiarizing their immune systems with the causative agents.
Owing to his extensive research on the subject, Mikhail is one of the most prominent figures in oncology. In his illustrious career, he has written several editorials on oncology and aging. His publications are popular, having received over 30,000 citations from his peers.
View Mikhail’s profile on Loop